Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.

ABSTRACT:

Background

A recent study has shown that phosphorylated c-Jun (p-c-Jun) interacts with TCF4 to form a complex that cooperatively enhances their transcriptional activity in the presence of beta-Catenin, and that their interaction is critical for mouse intestinal tumorigenesis. To determine the significance of these three proteins in human colorectal tumors, we analyzed their nuclear expression by immunohistochemistry.

Methods

we analyzed their nuclear expression by immunohistochemistry using paraffin-embedded specimens of 68 resected colorectal tumors, which consisted of 19 adenomas, 14 high-grade intraepithelial neoplasia (HGINs) and 35 adenocarcinomas. We also analyzed the expression of MMP7, which has functional AP-1 and TCF binding sites in its promoter.

Results

Ex

SUBMITTER: Takeda K 

PROVIDER: S-EPMC2585585 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature