Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase.

ABSTRACT:

Background

Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1.

Results

In this study, we investigated

SUBMITTER: Weber JM 

PROVIDER: S-EPMC2585588 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature