Preferred and avoided codon pairs in three domains of life.

ABSTRACT:

Background

Alternative synonymous codons are not used with equal frequencies. In addition, the contexts of codons - neighboring nucleotides and neighboring codons - can have certain patterns. The codon context can influence both translational accuracy and elongation rates. However, it is not known how strong or conserved the codon context preferences in different organisms are. We analyzed 138 organisms (bacteria, archaea and eukaryotes) to find conserved patterns of codon pairs.

Results

After removing the effects of single codon usage and dipeptide biases we discovered a set of neighboring codons for which avoidances or preferences were conserved in all three domains of life. Such biased codon pairs could be divided into subtypes on the basis of the nucleotide patterns that

SUBMITTER: Tats A 

PROVIDER: S-EPMC2585594 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature