Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program.

ABSTRACT: Essential hypertension is a principal cardiovascular risk factor whose origin remains unknown. Classical genetic studies have shown that blood pressure is at least partially heritable, opening a window to understanding the pathophysiology of essential hypertension in the human using modern genetic tools. The Wellcome Trust Case Control Consortium has recently published the results of screening the genomes of 2000 essential hypertension cases and 3000 controls using 500 000 genome-wide single nucleotide polymorphisms (SNPs). None of the variants proved to be genome-wide significant after correction for multiple tests but the most significantly associated SNPs (P<10(-5)) constitute a priority list that warrant follow-up in other studies. We describe here replication studies of the top six SN

SUBMITTER: Ehret GB 

PROVIDER: S-EPMC2585612 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature