The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.

ABSTRACT: The mammalian secondary palate exhibits morphological, pathological and molecular heterogeneity along the anteroposterior axis. Although the cell proliferation rates are similar in the anterior and posterior regions during palatal outgrowth, previous studies have identified several signaling pathways and transcription factors that specifically regulate the growth of the anterior palate. By contrast, no factor has been shown to preferentially regulate posterior palatal growth. Here, we show that mice lacking the transcription factor Mn1 have defects in posterior but not anterior palatal growth. We show that Mn1 mRNA exhibits differential expression along the anteroposterior axis of the developing secondary palate, with preferential expression in the middle and posterior regions during palat

SUBMITTER: Liu W 

PROVIDER: S-EPMC2586179 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature