Endocannabinoids and the control of energy homeostasis.

ABSTRACT: Endocannabinoids (ECBs) are ubiquitous lipid mediators that act through the same G protein-coupled receptors (CB1 and CB2) that recognize plant-derived cannabinoids. As regulators of metabolism, ECBs are anabolic: they increase the intake, promote the storage, and decrease the expenditure of energy. Recent work indicates that activation of peripheral CB1 receptors by ECBs plays a key role in the hormonal/metabolic changes associated with obesity/metabolic syndrome and may be targeted for its pharmacotherapy.

SUBMITTER: Kunos G 

PROVIDER: S-EPMC2586261 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature