Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity.

ABSTRACT:

Background

Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With the increased interest in malaria elimination, understanding the impact on transmission of ACT and other antimalarial drugs with different pharmacodynamics becomes a key issue. This study estimates the reduction in transmission that may be achieved by introducing different types of treatment for symptomatic P. falciparum malaria in endemic areas.

Methods and findings

We developed a mathematical model to predict the potential impact on transmission outcomes of introducing ACT as first-line treatment for uncomplicated malaria i

SUBMITTER: Okell LC 

PROVIDER: S-EPMC2586356 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature