Low spring constant regulates P-selectin-PSGL-1 bond rupture.

ABSTRACT: Forced dissociation of selectin-ligand bonds is crucial to such biological processes as leukocyte recruitment, thrombosis formation, and tumor metastasis. Although the bond rupture has been well known at high loading rate r(f) (>or=10(2) pN/s), defined as the product of spring constant k and retract velocity v, how the low r(f) (<10(2) pN/s) or the low k regulates the bond dissociation remains unclear. Here an optical trap assay was used to quantify the bond rupture at r(f)

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2586549 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature