Alpha-helical topology prediction and generation of distance restraints in membrane proteins.

ABSTRACT: The field of protein structure prediction has seen significant advances in recent years. Researchers have followed a multitude of approaches, including methods based on comparative modeling, fold recognition and threading, and first-principles techniques. It is noteworthy that the structure prediction of membrane proteins is comparatively less studied by researchers in the field. A membrane protein is characterized by a protein structure that extends into or through the lipid-lipid bilayer of a cell. The structure is influenced by the combination of the hydrophobic bilayer region, the direct interaction with the bilayer, and the aqueous external environment. Due to the difficulty in obtaining reliable experimental structures, accurate computational prediction of membrane proteins is of par

SUBMITTER: McAllister SR 

PROVIDER: S-EPMC2586566 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature