Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal.

ABSTRACT:

Objective

To report the definitive diagnosis of anti-NMDA receptor (NMDAR) encephalitis in four Japanese women previously diagnosed with "juvenile acute nonherpetic encephalitis" of unclear etiology, and to describe their long-term follow-up in the absence of tumor resection.

Methods

We extensively reviewed the case histories with current clinical and laboratory evaluations that include testing for antibodies to NR1/NR2 heteromers of the NMDAR in serum/CSF available from the time of symptom onset (4 to 7 years ago) and the present.

Results

All patients sequentially developed prodromal symptoms, psychosis, hypoventilation, severe orofacial dyskinesias, and bizarre immunotherapy-resistant involuntary movements that lasted 1 to 12 months. Two patients required mechanical

SUBMITTER: Iizuka T 

PROVIDER: S-EPMC2586938 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature