Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations.

ABSTRACT:

Objective

To report the frequency and type of antibodies against neuronal surface antigens (NSA-ab) in limbic encephalitis (LE).

Methods

Analysis of clinical features, neuropathologic findings, and detection of NSA-ab using immunochemistry on rat tissue and neuronal cultures in a series of 45 patients with paraneoplastic (23) or idiopathic (22) LE.

Results

NSA-ab were identified in 29 patients (64%; 12 paraneoplastic, 17 idiopathic). Thirteen patients had voltage-gated potassium channels (VGKC)-ab, 11 novel NSA (nNSA)-ab, and 5 NMDA receptor (NMDAR)-ab. nNSA-ab did not identify a common antigen and were more frequent in paraneoplastic than idiopathic LE (39% vs 9%; p = 0.03). When compared with VGKC-ab or NMDAR-ab, the nNSA associated more frequently with intraneurona

SUBMITTER: Graus F 

PROVIDER: S-EPMC2586945 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature