Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study.

ABSTRACT:

Objective

Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD.

Methods

Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities.

Results

In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly

SUBMITTER: Wang F 

PROVIDER: S-EPMC2586998 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature