Patient reported outcomes and analgesia use in osteoarthritis of the knee.

ABSTRACT:

Objective

Non-opioid analgesics (NOAs) are widely used to palliate osteoarthritis (OA) pain, however, their role in health-related quality of life (HRQoL) in OA has not been well studied. Here, we assess the relationship of pain, physical function, and HRQoL to NOA use in symptomatic knee OA.

Methods

NOA dose, pain, physical function, and HRQoL were evaluated longitudinally over 1 year in medial knee OA. Doses provided by subjects' weekly medication diaries were normalized to equi-analgesic ibuprofen-equivalents (IEs). Descriptive analyses at baseline, 1.5, and 12 months, and non-parametric comparisons of NOA with pain, physical function, and HRQoL at 1.5 months and over 12 months were performed.

Results

Seventy-one subjects (19 males and 52 females; mean 57+/-10.5 ye

SUBMITTER: Mody S 

PROVIDER: S-EPMC2587259 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature