The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.

ABSTRACT:

Background

In a recent study of several antidepressant drugs in hospitalized, non-Hispanic White patients, Binder et al. reported association of markers located within the FKBP5 gene with treatment response after 2 and 5 weeks. Individuals homozygous for the TT-genotype at one of the markers (rs1360780) reported more depressive episodes and responded better to antidepressant treatment. There was no association between markers in FKBP5 and disease. The present study aimed at studying the associated FKBP5 markers in the ethnically diverse Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample of non-hospitalized patients treated with citalopram.

Methods

We used clinical data and DNA samples from 1809 outpatients with non-psychotic major depressive disorder (DSM

SUBMITTER: Lekman M 

PROVIDER: S-EPMC2587308 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature