Efficient route to 4H-1,3-oxazines through ring expansion of isoxazoles by rhodium carbenoids.

ABSTRACT: Studies related to the total synthesis of elisabethin C led to the discovery of a rhodium-catalyzed cascade sequence involving isoxazole ring expansion and a [4 + 3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in the synthesis of a range of 4H-1,3-oxazines in 47-96% yield.

SUBMITTER: Manning JR 

PROVIDER: S-EPMC2587331 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature