Achievement and maintenance of sustained response during the Treatment for Adolescents With Depression Study continuation and maintenance therapy.

ABSTRACT:

Context

The Treatment for Adolescents With Depression Study evaluated fluoxetine (FLX), cognitive behavioral therapy (CBT), and FLX/CBT combination (COMB) vs pill placebo in 439 adolescents with major depressive disorder. Treatment consisted of 3 stages: (1) acute (12 weeks), (2) continuation (6 weeks), and (3) maintenance (18 weeks).

Objective

To examine rates of achieving and maintaining sustained response during continuation and maintenance treatments.

Design

Randomized controlled trial. Response was determined by blinded independent evaluators.

Setting

Thirteen US sites.

Patients

Two hundred forty-two FLX, CBT, and COMB patients in their assigned treatment at the end of stage 1.

Interventions

Stage 2 treatment varied based on stage 1 response.

SUBMITTER: Rohde P 

PROVIDER: S-EPMC2587406 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature