Patterns of evolutionary constraints on genes in humans.

ABSTRACT:

Background

Different regions in a genome evolve at different rates depending on structural and functional constraints. Some genomic regions are highly conserved during metazoan evolution, while other regions may evolve rapidly, either in all species or in a lineage-specific manner. A strong or even moderate change in constraints in functional regions, for example in coding regions, can have significant evolutionary consequences.

Results

Here we discuss a novel framework, 'BaseDiver', to classify groups of genes in humans based on the patterns of evolutionary constraints on polymorphic positions in their coding regions. Comparing the nucleotide-level divergence among mammals with the extent of deviation from the ancestral base in the human lineage, we identify patterns of evo

SUBMITTER: De S 

PROVIDER: S-EPMC2587479 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature