Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

ABSTRACT: [chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

SUBMITTER: Urgaonkar S 

PROVIDER: S-EPMC2588422 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature