The chromatin remodeler SPLAYED regulates specific stress signaling pathways.

ABSTRACT: Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic changes in chromatin structure. Alterations in chromatin structure are brought about by a number of different mechanisms, including chromatin modifications, which covalently modify histone proteins; incorporation of histone variants; and chromatin remodeling, which utilizes ATP hydrolysis to alter histone-DNA contacts. While considerable insight into the mechanisms of chromatin remodeling has been gained, the biological role of chromatin remodeling complexes beyond their function as regulators of cellular differentiation and development ha

SUBMITTER: Walley JW 

PROVIDER: S-EPMC2588541 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature