Assessment of protein set coherence using functional annotations.

ABSTRACT:

Background

Analysis of large-scale experimental datasets frequently produces one or more sets of proteins that are subsequently mined for functional interpretation and validation. To this end, a number of computational methods have been devised that rely on the analysis of functional annotations. Although current methods provide valuable information (e.g. significantly enriched annotations, pairwise functional similarities), they do not specifically measure the degree of homogeneity of a protein set.

Results

In this work we present a method that scores the degree of functional homogeneity, or coherence, of a set of proteins on the basis of the global similarity of their functional annotations. The method uses statistical hypothesis testing to assess the significance of the s

SUBMITTER: Chagoyen M 

PROVIDER: S-EPMC2588600 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature