Comparative genomics of wild type yeast strains unveils important genome diversity.

ABSTRACT:

Background

Genome variability generates phenotypic heterogeneity and is of relevance for adaptation to environmental change, but the extent of such variability in natural populations is still poorly understood. For example, selected Saccharomyces cerevisiae strains are variable at the ploidy level, have gene amplifications, changes in chromosome copy number, and gross chromosomal rearrangements. This suggests that genome plasticity provides important genetic diversity upon which natural selection mechanisms can operate.

Results

In this study, we have used wild-type S. cerevisiae (yeast) strains to investigate genome variation in natural and artificial environments. We have used comparative genome hybridization on array (aCGH) to characterize the genome variability of 16 yeas

SUBMITTER: Carreto L 

PROVIDER: S-EPMC2588607 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature