Analysis of the largest tandemly repeated DNA families in the human genome.

ABSTRACT:

Background

Tandemly Repeated DNA represents a large portion of the human genome, and accounts for a significant amount of copy number variation. Here we present a genome wide analysis of the largest tandem repeats found in the human genome sequence.

Results

Using Tandem Repeats Finder (TRF), tandem repeat arrays greater than 10 kb in total size were identified, and classified into simple sequence e.g. GAATG, classical satellites e.g. alpha satellite DNA, and locus specific VNTR arrays. Analysis of these large sequenced regions revealed that several "simple sequence" arrays actually showed complex domain and/or higher order repeat organization. Using additional methods, we further identified a total of 96 additional arrays with tandem repeat units greater than 2 kb (the detec

SUBMITTER: Warburton PE 

PROVIDER: S-EPMC2588610 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature