Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments.

ABSTRACT:

Background

The recent determination of the complete nucleotide sequence of several Mycobacterium tuberculosis (MTB) genomes allows the use of comparative genomics as a tool for dissecting the nature and consequence of genetic variability within this species. The multiple alignment of the genomes of clinical strains (CDC1551, F11, Haarlem and C), along with the genomes of laboratory strains (H37Rv and H37Ra), provides new insights on the mechanisms of adaptation of this bacterium to the human host.

Findings

The genetic variation found in six M. tuberculosis strains does not involve significant genomic rearrangements. Most of the variation results from deletion and transposition events preferentially associated with insertion sequences and genes of the PE/PPE family but not wi

SUBMITTER: Cubillos-Ruiz A 

PROVIDER: S-EPMC2590607 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature