A quantitative estimation of the global translational activity in logarithmically growing yeast cells.

ABSTRACT:

Background

Translation of messenger mRNAs makes significant contributions to the control of gene expression in all eukaryotes. Because translational control often involves fractional changes in translational activity, good quantitative descriptions of translational activity will be required to achieve a comprehensive understanding of this aspect of biology. Data on translational activity are difficult to generate experimentally under physiological conditions, however, translational activity as a parameter is in principle accessible through published genome-wide datasets.

Results

An examination of the accuracy of genome-wide expression datasets generated for Saccharomyces cerevisiae shows that the available datasets suffer from large random errors within studies as well as sy

SUBMITTER: von der Haar T 

PROVIDER: S-EPMC2590609 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature