Analysis of cytoskeletal and motility proteins in the sea urchin genome assembly.

ABSTRACT: The sea urchin embryo is a classical model system for studying the role of the cytoskeleton in such events as fertilization, mitosis, cleavage, cell migration and gastrulation. We have conducted an analysis of gene models derived from the Strongylocentrotus purpuratus genome assembly and have gathered strong evidence for the existence of multiple gene families encoding cytoskeletal proteins and their regulators in sea urchin. While many cytoskeletal genes have been cloned from sea urchin with sequences already existing in public databases, genome analysis reveals a significantly higher degree of diversity within certain gene families. Furthermore, genes are described corresponding to homologs of cytoskeletal proteins not previously documented in sea urchins. To illustrate the varying degre

SUBMITTER: Morris RL 

PROVIDER: S-EPMC2590651 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature