Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni.

ABSTRACT: The body's defense against schistosome infection can take many forms. For example, upon developing acute schistosomiasis, patients often have fever coinciding with larval maturation, migration and early oviposition. As the infection becomes established, the parasite comes under oxidative stress generated by the host immune system. The most common treatment for schistosomiasis is the anti-helminthic drug praziquantel. Its effectiveness, however, is limited due to its inability to kill schistosomes 2-4 weeks post-infection. Clearly there is a need for new anti-schistosomal drugs. We hypothesize that gene products expressed as part of a protective response against heat and/or oxidative stress are potential therapeutic targets for future drug development. Using a 12,166 element oligonucleotide

SUBMITTER: Aragon AD 

PROVIDER: S-EPMC2591067 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature