Cytomegalovirus infection and interferon-gamma modulate major histocompatibility complex class I expression on neural stem cells.

ABSTRACT: Cytomegalovirus (CMV) is the leading transmittable cause of congenital brain abnormalities in children and infection results in fatal ventriculoencephalitis in advanced acquired immunodeficiency syndrome (AIDS) patients. Pathology associated with CMV brain infection is seen predominantly in the periventricular region, an area known to harbor neural stem cells (NSCs). In the present study, using an adult model of murine CMV brain infection, the authors demonstrated that nestin-positive NSCs in the subventricular zone are susceptible to murine CMV infection. Furthermore, primary NSC cultures supported productive murine CMV replication with a 1000-fold increase in viral titers by 5 days post infection (d.p.i). Previous studies from the authors' laboratory demonstrated that CD8 lymphocytes wer

SUBMITTER: Cheeran MC 

PROVIDER: S-EPMC2592495 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature