Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila.

ABSTRACT:

Background

The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible for the maintenance of stable transcriptional patterns of many developmental regulators. They bind to specific regions of DNA and direct the post-translational modifications of histones, playing a role in the dynamics of chromatin structure.

Results

We have performed genome-wide expression studies of trx and ash2 mutants in Drosophila melanogaster. Using computational analysis of our microarray data, we have identified 25 clusters of genes potentially regulated by TRX. Most of these clusters consist of genes that encode structural proteins involved in cuticle formation. This organization appears to be a distinctive feature of the regulatory networks of TRX and other chromatin regulators,

SUBMITTER: Blanco E 

PROVIDER: S-EPMC2592712 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature