Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis.

ABSTRACT: Cryptosporidium parvum and Cryptosporidium hominis are two related species of apicomplexan protozoa responsible for the majority of human cases of cryptosporidiosis. In spite of their considerable public health impact, little is known about the population structures of these species. In this study, a battery of C. parvum and C. hominis isolates from seven countries was genotyped using a nine-locus DNA subtyping scheme. To assess the existence of geographical partitions, the multilocus genotype data were mined using a cluster analysis based on the nearest-neighbor principle. Within each country, the population genetic structures were explored by combining diversity statistical tests, linkage disequilibrium, and eBURST analysis. For both parasite species, a quasi-complete phylogenetic segreg

SUBMITTER: Tanriverdi S 

PROVIDER: S-EPMC2592928 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature