Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.

ABSTRACT:

Background

Primary ciliary dyskinesia (PCD) is a severe inherited disorder characterised by chronic respiratory disease, male infertility, and, in approximately 50% of affected individuals, a left-right asymmetry defect called situs inversus. PCD is caused by defects in substructures of the ciliary and flagellar axoneme, most commonly loss of the outer dynein arms. Although PCD is believed to involve mutations in many genes, only three have been identified.

Methods

To facilitate discovery of new PCD genes, we have used database searching and analysis to systematically identify the human homologues of proteins associated with the Chlamydomonas reinhardtii outer dynein arm, the best characterised outer arm of any species.

Results

We find that 12 out of 14 known Chlamydo

SUBMITTER: Pazour GJ 

PROVIDER: S-EPMC2593024 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature