Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients.

ABSTRACT:

Introduction

Variant R620W of protein tyrosine phosphatase non-receptor type 22 (PTPN22) has consistently been reported as a susceptibility factor for several autoimmune diseases. We investigated its role in susceptibility to psoriasis, the relevance of possibly other disease-causing variants, and interdependency of the major risk factor for psoriasis at PSORS1.

Methods

R620W was tested in a case-control study initially with 375 German patients and then with an enlarged sample of an additional 418 patients. Analyses were extended to linkage disequilibrium (LD) based haplotypes. Potential interaction between risk haplotypes of PTPN22 and the PSORS1 associated risk allele was tested by regression analysis. PTPN22 coding sequence was determined in 20 patients carrying the risk

SUBMITTER: Huffmeier U 

PROVIDER: S-EPMC2593025 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature