Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.

ABSTRACT: The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii has raised concern in health care settings worldwide. In order to understand the repertoire of resistance determinants and their organization and origins, we compared the genome sequences of three MDR and three drug-susceptible A. baumannii isolates. The entire MDR phenotype can be explained by the acquisition of discrete resistance determinants distributed throughout the genome. A comparison of closely related MDR and drug-susceptible isolates suggests that drug efflux may be a less significant contributor to resistance to certain classes of antibiotics than inactivation enzymes are. A resistance island with a variable composition of resistance determinants interspersed with transposons, integrons, and other mob

SUBMITTER: Adams MD 

PROVIDER: S-EPMC2593238 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature