Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.

ABSTRACT: During lytic infection, the genome of herpes simplex virus 1 (HSV-1) is associated with limited levels of histones but does not form a regular repeating nucleosomal structure. However, the previous observation that chromatin remodeling factors are recruited into viral replication compartments indicates that chromatin remodeling plays a role in HSV-1 gene expression and DNA replication. In this study we demonstrate the presence of histone H3 on HSV-1 DNA early in infection at levels equivalent to those found on a cellular gene. The proportion of viral DNA associated with histone H3 decreases at later times postinfection, independently of either viral DNA replication or transcription. We demonstrate that an immediate-early protein, infected cell protein 0 (ICP0), is required for both a reduc

SUBMITTER: Cliffe AR 

PROVIDER: S-EPMC2593313 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature