Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans.

ABSTRACT: Continuing antigenic drift allows influenza viruses to escape antibody-mediated recognition, and as a consequence, the vaccine currently in use needs to be altered annually. Highly conserved epitopes recognized by effector T cells may represent an alternative approach for the generation of a more universal influenza virus vaccine. Relatively few highly conserved epitopes are currently known in humans, and relatively few epitopes have been identified from proteins other than hemagglutinin and nucleoprotein. This prompted us to perform a study aimed at identifying a set of human T-cell epitopes that would provide broad coverage against different virus strains and subtypes. To provide coverage across different ethnicities, seven different HLA supertypes were considered. More than 4,000 peptid

SUBMITTER: Assarsson E 

PROVIDER: S-EPMC2593359 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature