PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells.

ABSTRACT:

Background

Many cells that migrate during normal embryonic development or in metastatic cancer first detach from an epithelium. However, this step is often difficult to observe directly in vivo, and the mechanisms controlling the ability of cells to leave the epithelium are poorly understood. In addition, once cells detach, they must assume a migratory phenotype, involving changes in cytoskeletal and signaling dynamics. Drosophila border cells provide a model system in which a combination of forward genetics and live-cell imaging can allow researchers to investigate the cellular and molecular mechanisms of epithelial cell detachment and migration in vivo.

Results

We identified the Drosophila homolog of the serine/threonine kinase PAR-1 (MARK/Kin1) in a screen for mutations t

SUBMITTER: McDonald JA 

PROVIDER: S-EPMC2593744 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature