Differential stability of flamingo protein complexes underlies the establishment of planar polarity.

ABSTRACT: BACKGROUND:The planar polarization of developing tissues is controlled by a conserved set of core planar polarity proteins. In the Drosophila pupal wing, these proteins adopt distinct proximal and distal localizations in apicolateral junctions that act as subcellular polarity cues to control morphological events. The core polarity protein Flamingo (Fmi) localizes to both proximal and distal cell boundaries and is known to have asymmetric activity, but the molecular basis of this asymmetric activity is unknown. RESULTS:We examine the role of Fmi in controlling asymmetric localization of polarity proteins in pupal wing cells. We find that Fmi interacts preferentially with distal-complex components, rather than with proximal components, and present evidence that there are different domain req

SUBMITTER: Strutt H 

PROVIDER: S-EPMC2593845 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature