Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.

ABSTRACT: The neural crest, a transient population of migratory cells, forms the craniofacial skeleton and peripheral nervous system, among other derivatives in vertebrate embryos. The transcriptional repressor Snail2 is thought to be crucial for the epithelial-to-mesenchymal transition (EMT) that promotes neural crest delamination from the neural tube; however, little is known about its downstream targets. To this end, we depleted avian Snail2 in the premigratory neural crest using morpholino antisense oligonucleotides and examined effects on potential targets by quantitative PCR. Several dorsal neural tube genes were upregulated by alleviating Snail2 repression; moreover, the cell adhesion molecule cadherin6B was derepressed within 30 minutes of blocking Snail2 translation. Examination of the chic

SUBMITTER: Taneyhill LA 

PROVIDER: S-EPMC2595139 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature