Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.

ABSTRACT:

Background

Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls.

Results

Genotype and allele frequencies did not d

SUBMITTER: Parwez Q 

PROVIDER: S-EPMC2596079 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature