Natural selection governs local, but not global, evolutionary gene coexpression networks in Caenorhabditis elegans.

ABSTRACT:

Background

Large-scale evaluation of gene expression variation among Caenorhabditis elegans lines that have diverged from a common ancestor allows for the analysis of a novel class of biological networks - evolutionary gene coexpression networks. Comparative analysis of these evolutionary networks has the potential to uncover the effects of natural selection in shaping coexpression network topologies since C. elegans mutation accumulation (MA) lines evolve essentially free from the effects of natural selection, whereas natural isolate (NI) populations are subject to selective constraints.

Results

We compared evolutionary gene coexpression networks for C. elegans MA lines versus NI populations to evaluate the role that natural selection plays in shaping the evolution of netwo

SUBMITTER: Jordan IK 

PROVIDER: S-EPMC2596099 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature