Gene expression variation between distinct areas of breast cancer measured from paraffin-embedded tissue cores.

ABSTRACT:

Background

Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate the biological variance between tumors and molecular markers were identified that led to new classification systems that provided better prognostic and predictive parameters. Archived FFPE samples represent an ideal source of tissue for translational research, as millions of tissue blocks exist from routine diagnostics and from clinical studies. These should be exploited to provide clinicians with more accurate prognostic and predictive information. Unfortunately, RNA derived from FFPE material is partially degraded and chemically modified and reliable gene expressio

SUBMITTER: Schobesberger M 

PROVIDER: S-EPMC2596175 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature