Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae.

ABSTRACT: The classical model of adaptive evolution in an asexual population postulates that each adaptive clone is derived from the one preceding it. However, experimental evidence has suggested more complex dynamics, with theory predicting the fixation probability of a beneficial mutation as dependent on the mutation rate, population size and the mutation's selection coefficient. Clonal interference has been demonstrated in viruses and bacteria but not in a eukaryote, and a detailed molecular characterization is lacking. Here we use three different fluorescent markers to visualize the dynamics of asexually evolving yeast populations. For each adaptive clone within one of our evolving populations, we identified the underlying mutations, monitored their population frequencies and used microarrays to

SUBMITTER: Kao KC 

PROVIDER: S-EPMC2596280 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature