Suppression of PGC-1alpha by Ethanol: Implications of Its Role in Alcohol Induced Liver Injury.

ABSTRACT: Ethanol has been known to cause injury to the liver and other tissues; however the molecular factors responsible for alcohol induced liver injury has not been fully understood. Recent studies indicate that reactive oxygen species (ROS) may play an important role in alcohol induced liver injury. Peroxisome proliferator activated receptor-gamma (PPAR-gamma)-coactivator 1alpha (PGC-1alpha) has been shown to be involved in defenses against ROS by inducing many ROS-detoxifying enzymes. However, the role of PGC-1alpha in alcohol induced liver injury has not been elucidated. Therefore, in this study, we examined the effect of alcohol on gene and protein expression of PGC-1alpha in H4-IIE cells (in vitro) and hepatic tissues (in vivo) by real-time PCR and Western blot, respectively. Our results sh

SUBMITTER: Chaung WW 

PROVIDER: S-EPMC2596315 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature