Molecular characterization of Helicobacter pylori strains isolated from cynomolgus monkeys (M. fascicularis).

ABSTRACT: We recently reported the occurrence of natural infection with H. pylori in a group of cynomolgus monkeys with chronic active gastritis and gastric erosions. The goal of the present study was to characterize and to compare strains isolated from animals originating from two different geographical areas. Gross and microscopic pathology determined at the time of necropsy was similar in all animals. H. pylori were isolated from specimens harvested in five monkeys (four from Vietnam and one from the Philippines) with gastritis. Isolates from monkeys bred in Vietnam had a similar DNA fingerprint pattern, which was distinct from that of isolates from a monkey bred in the Philippines. All strains were of the s1a vacA subtype, but all the 'Vietnamese' strains were cagA+ and all but one were iceA1 wh

SUBMITTER: Doi SQ 

PROVIDER: S-EPMC2596641 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature