Ontology highlight
ABSTRACT:
SUBMITTER: Altimus CM
PROVIDER: S-EPMC2596746 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Altimus C M CM Güler A D AD Villa K L KL McNeill D S DS Legates T A TA Hattar S S
Proceedings of the National Academy of Sciences of the United States of America 20081205 50
Light detected in the retina modulates several physiological processes including circadian photo-entrainment and pupillary light reflex. Intrinsically photosensitive retinal ganglion cells (ipRGCs) convey rod-cone and melanopsin-driven light input to the brain. Using EEGs and electromyograms, we show that acute light induces sleep in mice during their nocturnal active phase whereas acute dark awakens mice during their diurnal sleep phase. We used retinal mutant mouse lines that lack (i) the ipRG ...[more]