Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm.

ABSTRACT:

Background

Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA.

Methods

The -1562C > T and -1811A > T variants of the MMP-9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic diameter 19-22 mm) recruited from a population-based trial of screening for AAA. Levels of MMP-9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed by multivariable logistic regression.

Results

There was no association between the MMP-9-1562C > T (odds ratio (OR) 0.70 (95 p

SUBMITTER: Smallwood L 

PROVIDER: S-EPMC2597005 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature