Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.

ABSTRACT:

Background

Major depressive disorder (MDD) has been linked to inflammation, but this association may be due to common precursors to both depression and inflammation. Myeloperoxidase (MPO) is an inflammatory enzyme produced by activated leukocytes that predicts risk of coronary heart disease. We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors.

Methods

We examined 178 monozygotic and dizygotic middle-aged male twin pairs. We assessed MDD with the Structured Clinical Interview for DSM-IV. Blood markers of inflammation included MPO, interleukin-6, white blood cell count, C-reactive protein, tumor necrosis factor (TNF)-alpha, the TNF-alpha soluble receptor

SUBMITTER: Vaccarino V 

PROVIDER: S-EPMC2597204 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature