The cerebral microvasculature in schizophrenia: a laser capture microdissection study.

ABSTRACT:

Background

Previous studies of brain and peripheral tissues in schizophrenia patients have indicated impaired energy supply to the brain. A number of studies have also demonstrated dysfunction of the microvasculature in schizophrenia patients. Together these findings are consistent with a hypothesis of blood-brain barrier dysfunction in schizophrenia. In this study, we have investigated the cerebral vascular endothelium of schizophrenia patients at the level of transcriptomics.

Methodology/principal findings

We used laser capture microdissection to isolate both microvascular endothelial cells and neurons from post mortem brain tissue from schizophrenia patients and healthy controls. RNA was isolated from these cell populations, amplified, and analysed using two independent m

SUBMITTER: Harris LW 

PROVIDER: S-EPMC2597747 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature