Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women.

ABSTRACT:

Background

Oxidative stress has been recently suggested to play a part in the development of osteoporosis. Catalase is a major antioxidant enzyme that detoxifies hydrogen peroxide by converting it into water and oxygen, thereby preventing cellular injury by oxidative stress.

Aims

To examine the associations between the catalase gene (CAT) polymorphisms and bone mineral density (BMD) and bone turnover markers in postmenopausal Korean women.

Methods

All exons, their boundaries and the promoter region (approximately 1.5 kb) were directly sequenced in 24 individuals. Among 18 variants identified by a direct sequence method, four polymorphisms were selected and genotyped in all study participants (n = 560). BMD at the lumbar spine and proximal femur was measured using dual

SUBMITTER: Oh B 

PROVIDER: S-EPMC2597917 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature