A functional CD86 polymorphism associated with asthma and related allergic disorders.

ABSTRACT:

Background

Several studies have documented a substantial genetic component in the aetiology of allergic diseases and a number of atopy susceptibility loci have been suggested. One of these loci is 3q21, at which linkage to multiple atopy phenotypes has been reported. This region harbours the CD86 gene encoding the costimulatory B7.2 protein. The costimulatory system, consisting of receptor proteins, cytokines and associated factors, activates T cells and regulates the immune response upon allergen challenge.

Methods

We sequenced the CD86 gene in patients with atopy from 10 families that showed evidence of linkage to 3q21. Identified polymorphisms were analysed in a subsequent family-based association study of two independent Danish samples, respectively comprising 135 and 10

SUBMITTER: Corydon TJ 

PROVIDER: S-EPMC2597931 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature