A knowledge-based structure-discriminating function that requires only main-chain atom coordinates.

ABSTRACT:

Background

The use of knowledge-based potential function is a powerful method for protein structure evaluation. A variety of formulations that evaluate single or multiple structural features of proteins have been developed and studied. The performance of functions is often evaluated by discrimination ability using decoy structures of target proteins. A function that can evaluate coarse-grained structures is advantageous from many aspects, such as relatively easy generation and manipulation of model structures; however, the reduction of structural representation is often accompanied by degradation of the structure discrimination performance.

Results

We developed a knowledge-based pseudo-energy calculating function for protein structure discrimination. The function (Discrimina

SUBMITTER: Makino Y 

PROVIDER: S-EPMC2600639 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature